Conditions for the onset of the current filamentation instability in the laboratory

Current Filamentation Instability (CFI) is capable of generating strong magnetic fields relevant to explain radiation processes in astrophysical objects and lead to the onset of particle acceleration in collisionless shocks. Probing such extreme scenarios in the laboratory is still an open challenge. In this work, we investigate the possibility of using neutral $e^{-}$ $e^{+}$ beams to explore the CFI with realistic parameters, by performing 2D particle-in-cell simulations. We show that CFI can occur unless the rate at which the beam expands due to finite beam emittance is larger than the CFI growth rate and as long as the role of competing electrostatic two-stream instability (TSI) is negligible. We also show that the longitudinal energy spread, typical of plasma based accelerated electron-positron fireball beams, plays a minor role in the growth of CFI in these scenarios

The role of prestimulus activity in visual extinction.

Patients with visual extinction following right-hemisphere damage sometimes see and sometimes miss stimuli in the left visual field, particularly when stimuli are presented simultaneously to both visual fields. Awareness of left visual field stimuli is associated with increased activity in bilateral parietal and frontal cortex. However, it is unknown why patients see or miss these stimuli. Previous neuroimaging studies in healthy adults show that prestimulus activity biases perceptual decisions, and biases in visual perception can be attributed to fluctuations in prestimulus activity in task relevant brain regions. Here, we used functional MRI to investigate whether prestimulus activity affected perception in the context of visual extinction following stroke. We measured prestimulus activity in stimulus-responsive cortical areas during an extinction paradigm in a patient with unilateral right parietal damage and visual extinction. This allowed us to compare prestimulus activity on physically identical bilateral trials that either did or did not lead to visual extinction. We found significantly increased activity prior to stimulus presentation in two areas that were also activated by visual stimulation: the left calcarine sulcus and right occipital inferior cortex. Using dynamic causal modelling (DCM) we found that both these differences in prestimulus activity and stimulus evoked responses could be explained by enhanced effective connectivity within and between visual areas, prior to stimulus presentation. Thus, we provide evidence for the idea that differences in ongoing neural activity in visually responsive areas prior to stimulus onset affect awareness in visual extinction, and that these differences are mediated by fluctuations in extrinsic and intrinsic connectivity

Ultra-high brilliance multi-MeV γ\gamma-ray beam from non-linear Thomson scattering

We report on the generation of a narrow divergence ($\theta\approx 2.5$ mrad), multi-MeV ($E_\text{MAX} = 18$ MeV) and ultra-high brilliance ($\approx 2\times10^{19}$ photons s$^{-1}$ mm$^{-2}$ mrad $^{-2}$ 0.1\% BW) $\gamma$-ray beam from the scattering of an ultra-relativistic laser-wakefield accelerated electron beam in the field of a relativistically intense laser (dimensionless amplitude $a_0\approx2$). The spectrum of the generated $\gamma$-ray beam is measured, with MeV resolution, seamlessly from 6 MeV to 18 MeV, giving clear evidence of the onset of non-linear Thomson scattering. The photon source has the highest brilliance in the multi-MeV regime ever reported in the literature

An intervention framework for collaboration

This paper provides an intervention framework for collaboration to improve services. When collaboration is an intervention, its development and effectiveness depend on intervention logic. Intervention logic requires a precise conceptualization of collaboration. This conceptualization emphasizes its vital and unique components. It includes a developmental progression in which collaboration is contrasted with companion concepts. It also includes progress benchmarks, outcome measures, and logic models. These models depict relations among the benchmarks and outcomes, and they identify the mediating and moderating variables that account for collaboration's development and effectiveness. These models are designed to improve planning, evaluation, and their relations. This intervention framework for collaboration contrasts sharply with other conceptualizations and strategies. Although its aim is to unify and improve collaboration policy and practice, its inherent selectivity is an obvious limitation. [PUBLICATION ABSTRACT

Laser-driven electron source suitable for single-shot Gy-scale irradiation of biological cells at dose-rates exceeding 101010^{10} Gy/s

We report on the first systematic characterisation of a tuneable laser-driven electron source capable of delivering Gy-scale doses in a duration of 10 - 20 ps, thus reaching unprecedented dose rates in the range of $10^{10} - 10^{12}$ Gy/s. Detailed characterisation of the source indicates, in agreement with Monte-Carlo simulations, single-shot delivery of multi-Gy doses per pulse over cm-scale areas, with a high degree of spatial uniformity. The results reported here confirm that a laser-driven source of this kind can be used for systematic studies of the response of biological cells to picosecond-scale radiation at ultra-high dose rates.Comment: submitted for publicatio